SERYL-TRNA SYNTHETASES IN TRANSLATION AND BEYOND

Seryl-tRNA Synthetases in Translation and Beyond

For a long time seryl-tRNA synthetases (SerRSs) stood as an archetypal, canonical aminoacyl-tRNA synthetases (aaRS), exhibiting only basic tRNA aminoacylation activity and with no moonlighting functions beyond protein biosynthesis.The picture has changed substantially in recent years after the discovery that SerRSs play an important role in antibio

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A streamlined proximity extension assay using POEGMA polymer-coated magnetic beads for enhanced protein detection

The detection of protein biomarkers presenting at low concentrations in biological fluids is essential for disease diagnosis and therapeutic monitoring.While magnetic beads-based solid-phase immunoassays have shown promise in achieving high sensitivity for detecting low-abundance proteins, existing protocols suffer from limitations such as the cumb

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